This Evaluation was carried out retrospectively, and was not driven to detect any pre-specified variance in adverse reactions.

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Indicate sildenafil plasma concentrations measured once the administration of just one oral dose of 100 mg to healthier male volunteers is depicted beneath:

Physicians must recommend sufferers to halt having PDE5 inhibitors, which includes VIAGRA, and look for prompt health care notice from the event of unexpected lessen or loss of Listening to. These events, which may be accompanied by tinnitus and dizziness, have been noted in temporal association to the intake of PDE5 inhibitors, which includes VIAGRA.

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Results of Other Medications on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (main route) and CYP2C9 (minimal route). Hence, inhibitors of these isoenzymes may well reduce sildenafil clearance and inducers of these isoenzymes could raise sildenafil clearance.

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The signify profiles in the change from baseline in standing systolic hypertension in subjects taken care of with doxazosin together with 100 mg VIAGRA or matching placebo are demonstrated in Determine 4.

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In several conditions, health-related comply with-up data was minimal. It truly is not possible to find out regardless of whether these documented situations are similar straight to the usage of VIAGRA, on the client's underlying danger factors for hearing loss, a mix of these components, or to other things [see WARNINGS AND Safety measures and Individual Details].

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